If you run into upgrading your McAfee EPO server then here is a cool upgrade table.
Make note that some versions are EOL (end of life)
- ePO 5.0 reached end of life (EOL) on December 31, 2014, and is no longer supported.
- ePO 4.6 reached end of life (EOL) on December 31, 2015, and is no longer supported
Also make sure your OS is upported. here a overview table from McAfee website
Server operating systems
| Microsoft operating system | ePO 4.6 (EOL) |
ePO 5.0 (EOL) |
ePO 5.1 | ePO 5.3 |
| Microsoft Windows Server 2012 R2 (Standard and Datacenter) |
No | No | Yes1 | Yes |
| Microsoft Windows Server 2012 (Standard and Datacenter) |
No2 | Â Yes | Yes | Yes |
| Microsoft Windows Server 2008 Release 2 (64-bit) (Standard, Enterprise, and Datacenter) |
Yes | Â Yes | Yes | Yes |
| Microsoft Windows Server 2008 (64-bit) (Standard, Enterprise, and Datacenter) |
Yes | Yes3 | Yes3 | Yes |
| Microsoft Windows Server 2008 (32-bit) (Standard, Enterprise, and Datacenter) |
Yes | No | No | No |
| Microsoft Windows 2003 Storage Server | No | No | No | No |
| Microsoft Windows Server 2003 Release 2 (32-bit) | Yes | No | No | No |
| Microsoft Windows Server 2003 Release 2 (64-bit) | Yes | No | No | No |
| Microsoft Windows Server 2003 (32-bit) | Yes | No | No | No |
| Microsoft Windows Server 2003 (64-bit) | Yes | No | No | No |
| Microsoft Windows 2003 Web | No | No | No | No |
If you need to know wich database, internet browser or virtual infrastructure is supported the here is the link to McAfee KB51569
https://kc.mcafee.com/corporate/index?page=content&id=KB51569
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